Ligustrazine ameliorates acute kidney injury through downregulation of NOD2-mediated inflammation
Identifieur interne : 000121 ( an2020/Analysis ); précédent : 000120; suivant : 000122Ligustrazine ameliorates acute kidney injury through downregulation of NOD2-mediated inflammation
Auteurs : Guosheng Jiang ; Rui Xin ; Wendan Yuan ; Lixia Zhang ; Xianghui Meng ; Wangnan Sun ; Huirong Han ; Yun Hou ; Lin Wang [République populaire de Chine] ; Pengchao DuSource :
- International Journal of Molecular Medicine [ 1107-3756 ] ; 2020.
Abstract
Ligustrazine has been used to alleviate clinical acute kidney injury (AKI); however, the underlying molecular mechanisms are poorly understood. In order to further elucidate the molecular mechanism underlying its occurrence, the role of nucleotide-binding oligomerization domain-containing 2 (NOD2) in AKI was investigated in the present study, and the results indicated that ligustrazine exerts an important protective effect against AKI
Url:
DOI: 10.3892/ijmm.2020.4464
PubMed: 31985025
PubMed Central: 7015130
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ligustrazine ameliorates acute kidney injury through downregulation of NOD2-mediated inflammation</title><author><name sortKey="Jiang, Guosheng" sort="Jiang, Guosheng" uniqKey="Jiang G" first="Guosheng" last="Jiang">Guosheng Jiang</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Xin, Rui" sort="Xin, Rui" uniqKey="Xin R" first="Rui" last="Xin">Rui Xin</name><affiliation><nlm:aff id="af2-ijmm-45-03-0731">Center for Reproductive Medicine, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, The Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, Shandong 250021</nlm:aff><wicri:noCountry code="subfield">Shandong 250021</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Wendan" sort="Yuan, Wendan" uniqKey="Yuan W" first="Wendan" last="Yuan">Wendan Yuan</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Lixia" sort="Zhang, Lixia" uniqKey="Zhang L" first="Lixia" last="Zhang">Lixia Zhang</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Meng, Xianghui" sort="Meng, Xianghui" uniqKey="Meng X" first="Xianghui" last="Meng">Xianghui Meng</name><affiliation><nlm:aff id="af3-ijmm-45-03-0731">Microwave Treatment Department, Central Hospital of Zibo (GaoQing Branch Courts), Zibo, Shandong 256300</nlm:aff><wicri:noCountry code="subfield">Shandong 256300</wicri:noCountry></affiliation></author><author><name sortKey="Sun, Wangnan" sort="Sun, Wangnan" uniqKey="Sun W" first="Wangnan" last="Sun">Wangnan Sun</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Han, Huirong" sort="Han, Huirong" uniqKey="Han H" first="Huirong" last="Han">Huirong Han</name><affiliation><nlm:aff id="af4-ijmm-45-03-0731">Department of Anesthesiology and Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, Weifang Medical University, Weifang, Shandong 261053</nlm:aff><wicri:noCountry code="subfield">Shandong 261053</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Yun" sort="Hou, Yun" uniqKey="Hou Y" first="Yun" last="Hou">Yun Hou</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-03-0731">Department of Gerontology, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gerontology, The Second Hospital of Shandong University, Jinan, Shandong 250000</wicri:regionArea><wicri:noRegion>Shandong 250000</wicri:noRegion></affiliation></author><author><name sortKey="Du, Pengchao" sort="Du, Pengchao" uniqKey="Du P" first="Pengchao" last="Du">Pengchao Du</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31985025</idno><idno type="pmc">7015130</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015130</idno><idno type="RBID">PMC:7015130</idno><idno type="doi">10.3892/ijmm.2020.4464</idno><date when="2020">2020</date><idno 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through downregulation of NOD2-mediated inflammation</title><author><name sortKey="Jiang, Guosheng" sort="Jiang, Guosheng" uniqKey="Jiang G" first="Guosheng" last="Jiang">Guosheng Jiang</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Xin, Rui" sort="Xin, Rui" uniqKey="Xin R" first="Rui" last="Xin">Rui Xin</name><affiliation><nlm:aff id="af2-ijmm-45-03-0731">Center for Reproductive Medicine, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, The Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, Shandong 250021</nlm:aff><wicri:noCountry code="subfield">Shandong 250021</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Wendan" sort="Yuan, Wendan" uniqKey="Yuan W" first="Wendan" last="Yuan">Wendan Yuan</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Lixia" sort="Zhang, Lixia" uniqKey="Zhang L" first="Lixia" last="Zhang">Lixia Zhang</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Meng, Xianghui" sort="Meng, Xianghui" uniqKey="Meng X" first="Xianghui" last="Meng">Xianghui Meng</name><affiliation><nlm:aff id="af3-ijmm-45-03-0731">Microwave Treatment Department, Central Hospital of Zibo (GaoQing Branch Courts), Zibo, Shandong 256300</nlm:aff><wicri:noCountry code="subfield">Shandong 256300</wicri:noCountry></affiliation></author><author><name sortKey="Sun, Wangnan" sort="Sun, Wangnan" uniqKey="Sun W" first="Wangnan" last="Sun">Wangnan Sun</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Han, Huirong" sort="Han, Huirong" uniqKey="Han H" first="Huirong" last="Han">Huirong Han</name><affiliation><nlm:aff id="af4-ijmm-45-03-0731">Department of Anesthesiology and Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, Weifang Medical University, Weifang, Shandong 261053</nlm:aff><wicri:noCountry code="subfield">Shandong 261053</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Yun" sort="Hou, Yun" uniqKey="Hou Y" first="Yun" last="Hou">Yun Hou</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-03-0731">Department of Gerontology, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gerontology, The Second Hospital of Shandong University, Jinan, Shandong 250000</wicri:regionArea><wicri:noRegion>Shandong 250000</wicri:noRegion></affiliation></author><author><name sortKey="Du, Pengchao" sort="Du, Pengchao" uniqKey="Du P" first="Pengchao" last="Du">Pengchao Du</name><affiliation><nlm:aff id="af1-ijmm-45-03-0731">School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003</nlm:aff><wicri:noCountry code="subfield">Shandong 264003</wicri:noCountry></affiliation></author></analytic><series><title level="j">International Journal of Molecular Medicine</title><idno type="ISSN">1107-3756</idno><idno type="eISSN">1791-244X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ligustrazine has been used to alleviate clinical acute kidney injury (AKI); however, the underlying molecular mechanisms are poorly understood. In order to further elucidate the molecular mechanism underlying its occurrence, the role of nucleotide-binding oligomerization domain-containing 2 (NOD2) in AKI was investigated in the present study, and the results indicated that ligustrazine exerts an important protective effect against AKI <italic>in vivo</italic> by inhibiting the upregulation of NOD2 expression and reducing apoptosis of kidney cells following ischemia/reperfusion injury in rat models. Furthermore, the inhibitory role of ligustrazine on the upregulation of NOD2 and apoptosis of kidney cells induced by CoCl<sub>2</sub> and oxygen and glucose deprivation followed by reoxygenation was investigated in <italic>in vitro</italic> experiments. The effect of ligustrazine on NOD2 downregulation was partially blocked by inhibiting autophagy. To the best of our knowledge, the results of the present study are the first to provide evidence that ligustrazine can inhibit NOD2-mediated inflammation to protect against renal injury, which may be in part attributed to the induction of autophagy. These findings may help design and develop new approaches and therapeutic strategies for AKI to prevent the deterioration of renal function.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Eltzschig, Hk" uniqKey="Eltzschig H">HK Eltzschig</name></author><author><name sortKey="Eckle, T" uniqKey="Eckle T">T Eckle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabb, H" uniqKey="Rabb H">H Rabb</name></author><author><name sortKey="Griffin, Md" uniqKey="Griffin M">MD Griffin</name></author><author><name sortKey="Mckay, Db" uniqKey="Mckay D">DB McKay</name></author><author><name sortKey="Swaminathan, S" uniqKey="Swaminathan S">S Swaminathan</name></author><author><name sortKey="Pickkers, P" uniqKey="Pickkers P">P Pickkers</name></author><author><name sortKey="Rosner, Mh" uniqKey="Rosner M">MH Rosner</name></author><author><name sortKey="Kellum, Ja" uniqKey="Kellum J">JA 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Du</name><name sortKey="Han, Huirong" sort="Han, Huirong" uniqKey="Han H" first="Huirong" last="Han">Huirong Han</name><name sortKey="Hou, Yun" sort="Hou, Yun" uniqKey="Hou Y" first="Yun" last="Hou">Yun Hou</name><name sortKey="Jiang, Guosheng" sort="Jiang, Guosheng" uniqKey="Jiang G" first="Guosheng" last="Jiang">Guosheng Jiang</name><name sortKey="Meng, Xianghui" sort="Meng, Xianghui" uniqKey="Meng X" first="Xianghui" last="Meng">Xianghui Meng</name><name sortKey="Sun, Wangnan" sort="Sun, Wangnan" uniqKey="Sun W" first="Wangnan" last="Sun">Wangnan Sun</name><name sortKey="Xin, Rui" sort="Xin, Rui" uniqKey="Xin R" first="Rui" last="Xin">Rui Xin</name><name sortKey="Yuan, Wendan" sort="Yuan, Wendan" uniqKey="Yuan W" first="Wendan" last="Yuan">Wendan Yuan</name><name sortKey="Zhang, Lixia" sort="Zhang, Lixia" uniqKey="Zhang L" first="Lixia" last="Zhang">Lixia Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Lin" sort="Wang, Lin" 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